Cell shape modulates cellular response to stimuli
Demonstrated that the cell shape can modulate the transcriptional response to external stimuli such as compressive load and inflammation.
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Research
Measuring the contribution of cell mechanics to the selective activation of fibroblasts by cancer
Established the existence of activation primed cell shapes using multimodal-multivariate analysis. Demonstrated a causal relationship between cell geometry and activation. In addition, our study presents a framework for studying single cell heterogeneity and highlights the importance of the geometric state of fibroblasts in the interpretation of environmental signals.
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